Showing metabocard for gamma-Butyrolactone (HMDB0000549)
gamma-Butyrolactone: ... and creamy tasting compound. Gamma-butyrolactone exists in all living species, ranging from bacteria to plants to humans. It can be endogenously produced from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. ... COMPND NULL SOURCE NULL KEYWDS NULL EXPDTA NULL AUTHOR Marvin …
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Process for gamma-butyrolactone production
Additionally, labeling allows the exact percentage in bioplastics that came from renewable sources (e.g., plant derivatives) can be known via ASTM D6866—an industrial application of radiocarbon dating. ... Example 9 Generation of Gamma-Butyrolactone from the Pyrolysis of a Genetically Engineered Microbe Producing Poly-4-Hydroxybutyrate ...
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gamma-Butyrolactones: Streptomyces signalling molecules …
production and that most of the g-butyrolactone receptors could be pathway-specific. It is interesting that, for the first time, a receptor protein from a non-streptomycete has been …
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The Global Gamma Butyrolactone Market is expected to grow
Global Gamma Butyrolactone Market 2022-2026 The analyst has been monitoring the gamma butyrolactone market and it is poised to grow by $ 799. 45 mn during 2022-2026, progressing at a CAGR of 6. 27 ...
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Identification of Gamma-Butyrolactone in JUUL Liquids
Abstract Gamma-butyrolactone (GBL), a commonly used industrial solvent, is used recreationally as a central nervous system (CNS) depressant and, therefore, is a …
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SAFETY DATA SHEET Revision Date 08/02/2023 Version 6
Product name : γ-Butyrolactone Product Number : B103608 Brand : Aldrich CAS-No. : 96-48-0 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Synthesis of substances 1.3 Details of the supplier of the safety data sheet Company : Sigma-Aldrich Inc. 3050 SPRUCE ST
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Gamma-Butyrolactone
Gamma-Butyrolactone. The conversion of GBL to GHB by peripheral lactonases (or by nonenzymatic hydrolysis), and 1,4-BD by alcohol dehydrogenase and aldehyde dehydrogenase (Snead & Gibson, 2005) might explain the different time profile of each compound for the cataleptic responses during the observation period (60–70min) …
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SAFETY DATA SHEET
SAFETY DATA SHEET Revision Date 25-Dec-2021 Revision Number 4 1. Identification Product Name 2-Hydroxy-y-butyrolactone No. : AC275070000; AC275070050; AC275070250 Synonyms alpha-Hydroxy-gamma-butyrolactone. Recommended Use Laboratory chemicals. Uses advised against Food, drug, pesticide or biocidal product …
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Gamma-Butyrolactone
2.8.5 Deletion of γ-Butyrolactone Receptor Genes. γ-Butyrolactone (GBL) regulatory systems are important in regulation of secondary metabolism in Streptomyces ( Du et al., 2011; Horinouchi and Beppu, 2007; Takano, 2006; Willey and Gaskell, 2011 ). γ-Butyrolactones are a family of hormone-like signal molecules, and at least 60% of ...
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Plant Growth Suppressive Activity of (R)-3-(7'-Aryl-9'-hydroxyprop …
3-(7'-Aryl-9'-hydroxyprop-8'-yl)coumarin, which is a structural isomer of a Z-2-hydroxybenzylidene-γ-butyrolactone-type lignan, was stereoselectively synthesized and subjected to plant growth regulation examination. (R)-4'-Methoxyphenyl derivative 3 showed stereospecific plant growth suppressive activity. The significance of the presence of …
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Global Gamma-Butyrolactone Market Insights (2020 to 2026)
3.2.1 Data Sources 3.2.2 Assumptions 3.3 Research Method Chapter 4 Market Landscape ... Chapter 15 Global Gamma-Butyrolactone (Gbl) Market Forecast (2021-2026) 15.1 Gamma-Butyrolactone (Gbl ...
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Butanediol Market Size, Growth, Analysis & Forecast, 2030
USA's Butanediol production rate was modest, and inventories were ample in North America. The global Butanediol market has expanded to reach approximately 3300 thousand tonnes in 2022 and is expected to grow at a healthy CAGR of 4.38% during the forecast period until 2030. Butanediol is a colorless, thick, water-soluble organic compound.
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GHB
What is GHB? GHB (gamma hydroxybutyrate) is a depressant drug, which means it slows down messages travelling between the brain and body. GBL (gamma butyrolactone) and 1,4-BD (1,4-butanediol) are chemicals that are closely related to GHB. Once GBL or 1,4-BD enter the body, they convert to GHB almost immediately. 1.
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Frontiers | Functional Polymers and Polymeric Materials From …
Sustainable chemistry requires application of green processes and often starting materials originate from renewable resources. Biomass-derived monomers based on five-membered γ-butyrolactone ring represent suitable candidates to replace sources of fossil origin. α-Methylene-γ-butyrolactone, β-hydroxy-α-methylene-γ-butyrolactone, and β- and γ …
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Alpha-methylene-gamma-butyrolactones: versatile skin bioactive …
10.1002/tcr.200900013. Natural products containing an alpha-methylene-gamma-butyrolactone moiety, mainly of the sesquiterpene type, are widely observed in plants, which upon coming into contact with skin, will induce major skin toxicological side effects or phytodermatitis. Indeed two main dermatological pathologies have been associated with …
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Formation of GHB from hydrolysis of GBL in pure …
Toxicity of gamma-butyrolactone (72-hr lethal concentration predicted to kill 50% was 47 ppm) indicated effects in THF treatments can result from gamma-butyrolactone toxicity.
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SAFETY DATA SHEET
Product Description: y-Butyrolactone No. : 108130000; 108130010; 108130025; 10813100 Synonyms 4-Hydroxybutyric acid gamma-lactone; BLO CAS No 96-48-0 EC No 202-509-5 Molecular Formula C4 H6 O2 1.2. Relevant identified uses of the substance or mixture and uses advised against Recommended Use Laboratory chemicals.
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gamma-Butyrolactone: Uses, Interactions, Mechanism of Action
gamma-Butyrolactone. DrugBank Accession Number. DB04699. Background. One of the furans with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.
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Recent Developments in Lactone Monomers and Polymer …
Lactones are a group of compounds that have been known for several decades. The commercial importance of lactones results from the possibility of manufacturing of a broad scope of derivatives and polymers with a wide spectrum of applications. In this work the synthesis and characterization of simple lactones are …
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γ-Hydroxybutyric Acid: Pharmacokinetics, Pharmacodynamics, …
γ-Hydroxybutyric acid (GHB) is an endogenous short-chain fatty acid (C 4 H 8 O 3) present in the central nervous system (CNS) ( Fig. 1) ( 1) and an analog of y-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the CNS. GHB was first synthesized in 1874 but was not investigated for a potential clinical use until the 1960s …
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Selective Oxidation of Tetrahydrofuran to Gamma …
The selective oxidation of tetrahydrofuran (THF) to gamma-butyrolactone (GBL) on spinel ZnFe2O4 nanoparticles (ZFNPs) was investigated. The catalyst was prepared with the coprecipitation method …
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Current Insights on the Impact of Gamma-Hydroxybutyrate (GHB) …
Gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) are readily available as industrial solvents and can be consumed and converted by the body to GHB. ... Citation 32 In the United Kingdom, data from a number of sources including drug treatment and poisoning databases indicate an increase in GHB use up to 2015 that has now …
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PDEA adds Gamma-Butyrolactone (GBL) to list of dangerous drugs
He explained that Gamma-Butyrolactone is a liquid compound used as a solvent and sometimes taken as a recreational drug being metabolized in the body producing an active substance called "Gamma-Hydroxybutyrate" or GHB. ... or are sources thereof, as dangerous drugs, was also adopted by the Dangerous Drugs Board (DDB). ...
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Safety Data Sheet
Gamma Butyrolactone CAS 96-48-0 Purity: >99% Trace Impurities: butanediol, acidic materials, acetals and aldehydes 2.1. Classification of the substance or mixture: Classification of Labeling in accordance with the CLP Regulations: Index No International Chemical Identification EC No CAS No Classification Labeling Specific Conc. Limits, M …
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A Review of the Pharmacological Activities and Recent Synthetic
Several γ -butyrolactone-containing drugs have been FDA-approved and used in clinic for diverse purposes such as diuretics, anticancer agents, contraceptive …
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Gamma Butyrolactone
Gamma Butyrolactone. ... A number of active principles are reported from this plant, which mainly include diterpene lactones, flavonoids, and polyphenols (Li et al., 2007, ... (Box 44.5). γ-Hydroxybutyrate exposure may also arise from unexpected sources (Box 44.6).
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Simultaneous Quantification of γ-Hydroxybutyrate, γ-Butyrolactone…
Figure 2 shows that the peak observed at m/z 87.1 was the product ion of GHB and the precursor ion of GBL. This was attributed to GHB losing a water molecule within the instrument ion source, leading to the formation of GBL. In addition, GBL can gain one molecule of water and protonated to form the same m/z of GHB. In this case, the …
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Comparative and pangenomic analysis of the genus …
Polyketide, non-ribosomal peptide, and gamma-butyrolactone biosynthetic enzymes are primarily strain specific while ectoine and some terpene biosynthetic …
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Frontiers | Recent advances of γ-aminobutyric acid: …
1 Introduction. γ-aminobutyric acid (GABA), also known as 4-aminobutyric acid (), is a non-protein amino acid that naturally and widely occurs in animals, plants, and microorganisms.Its empirical formula is C …
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GBL | Drugs-Forum
GBL. Gamma-Butyrolactone is an addictive depressant used for its euphoric and sleep inducing effects. GBL is used to produce the related GHB, but is also consumed on its own. GBL can be synthesized from gamma-hydroxybutyric acid (GHB) by removal of water or by distillation from such a mixture. GHB is a naturally occurring fatty …
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